EPYC 7543 vs Xeon Platinum 8380

CPU

GPU

EPYC 7543

32 Cores64 Thrd225 WWMax: 3.7 GHz2021

EPYC family

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Xeon Platinum 8380

40 Cores80 Thrd270 WWMax: 3.4 GHz2021

Similar parts

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EPYC 7543 vs Xeon Platinum 8380 Performance Spectrum

EPYC 7543

32 / 64

62,952

+1.0%

Ryzen AI 9 HX 370

Ryzen AI Max 390

Ryzen Threadripper PRO 5955WX

Ryzen 9 9955HX

Ryzen Threadripper 3990X

Ryzen Threadripper 9960X

Ryzen Threadripper PRO 9975WX

Ryzen Threadripper PRO 7985WX

Xeon Platinum 8380

40 / 80

62,318

0.0%

About PassMark

PassMark CPU Mark evaluates processor speed through complex mathematical computations. It provides a reliable metric to compare multi-core performance, where higher scores indicate faster processing for multitasking, gaming, and heavy workloads.

EPYC 7543 vs Xeon Platinum 8380 FPS Benchmarks

Predicted gaming performance across popular games. Tested paired with GeForce RTX 5090 to isolate CPU performance.

Search any supported game below to compare 1080p FPS for both components.

EPYC 7543 vs Xeon Platinum 8380: Pros, Cons & Final Verdict

See where each CPU makes more sense in practice: gaming, heavier work, platform cost, power draw, and upgrade path.

EPYC 7543

2021

Why buy it

✅+1% higher PassMark.
✅+326.7% larger total L3 cache (256 MB vs 60 MB).
✅Draws 225W instead of 270W, a 45W reduction.
✅100% more PCIe lanes (128 vs 64) for storage and expansion-heavy builds.

Trade-offs

❌Lower PassMark per dollar, at 6.1 vs 31.0 PassMark/$ ($10,257 MSRP vs $2,010 MSRP).
❌No AVX-512 support for niche heavy compute workloads where it can matter.

Xeon Platinum 8380

2021

Why buy it

✅Costs $8,247 less on MSRP ($2,010 MSRP vs $10,257 MSRP).
✅Delivers 405.2% more PassMark for each dollar spent, at 31.0 vs 6.1 PassMark/$ ($2,010 MSRP vs $10,257 MSRP).
✅AVX-512 support for select workstation, AI, and scientific workloads.

Trade-offs

❌Lower PassMark (62,318 vs 62,952).
❌Smaller total L3 cache (60 MB vs 256 MB).
❌20% higher power demand at 270W vs 225W.

Quick Answers

So, is Xeon Platinum 8380 better than EPYC 7543?

It depends on what you want from the system. For gaming, Xeon Platinum 8380 is ahead with a 1.3% average FPS lead across 50 shared CPU game tests in our data. For rendering, compiling, streaming, and heavier multitasking, EPYC 7543 pulls ahead with 1% better PassMark. EPYC 7543 also has the bigger cache pool with 326.7% larger total L3 cache (256 MB vs 60 MB).

Which one is better for streaming, content creation, and heavy multitasking?

For streaming, content creation, and heavier multitasking, EPYC 7543 is the stronger fit. You are getting 1% better PassMark, backed by 32 cores and 64 threads. It also has the larger cache pool with 326.7% larger total L3 cache (256 MB vs 60 MB).

Which one is the smarter buy today, not just the cheaper CPU?

Xeon Platinum 8380 is the better buy right now. Xeon Platinum 8380 comes in $8,247 cheaper on MSRP at $2,010 MSRP versus $10,257 MSRP, and it still gives you a 1.3% average FPS lead across 50 shared CPU game tests in our data. The compromise is that EPYC 7543 is still stronger for heavier multi-core work with 1% better PassMark. It is also 405.2% better value on MSRP (31.0 vs 6.1 PassMark/$), so you are getting the faster CPU without taking a value hit on paper.

Which one is more future-proof for 2026 and beyond?

Xeon Platinum 8380 makes more sense long term for 2026 and beyond. You are getting AVX-512 support for heavier modern compute workloads. That makes it the safer long-term bet.

EPYC 7543 vs Xeon Platinum 8380 Technical Specifications

Side-by-side specs, architecture details, clocks, memory, power, and platform differences.

EPYC 7543

The EPYC 7543 is manufactured by AMD. It was released in 15 March 2021 (4 years ago). It is based on the Milan (2021−2023) architecture. It features 32 cores and 64 threads. Base frequency is 2.8 GHz, with boost up to 3.7 GHz. L3 cache: 256 MB (total). L2 cache: 512 kB (per core). Built on 7 nm+ process technology. Socket: SP3. Thermal design power (TDP): 225 Watt. Memory support: DDR4-3200. Passmark benchmark score: 62,952 points. Launch price was $3,761.

Xeon Platinum 8380

The Xeon Platinum 8380 is manufactured by Intel. It was released in 2021-04-06. It is based on the Ice Lake-SP (2021) architecture. It features 40 cores and 80 threads. Base frequency is 2.3 GHz, with boost up to 3.4 GHz. L3 cache: 60 MB (total). L2 cache: 1 MB (per core). Built on 10 nm process technology. Socket: LGA4189. Thermal design power (TDP): 270 Watt. Memory support: DDR4-3200. Passmark benchmark score: 62,318 points. Launch price was $5,846.

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Processing Power

The EPYC 7543 packs 32 cores / 64 threads, while the Xeon Platinum 8380 offers 40 cores / 80 threads — the Xeon Platinum 8380 has 8 more cores. Boost clocks reach 3.7 GHz on the EPYC 7543 versus 3.4 GHz on the Xeon Platinum 8380 — a 8.5% clock advantage for the EPYC 7543 (base: 2.8 GHz vs 2.3 GHz). The EPYC 7543 uses the Milan (2021−2023) architecture (7 nm+), while the Xeon Platinum 8380 uses Ice Lake-SP (2021) (10 nm). In PassMark, the EPYC 7543 scores 62,952 against the Xeon Platinum 8380's 62,318 — a 1% lead for the EPYC 7543. L3 cache: 256 MB (total) on the EPYC 7543 vs 60 MB (total) on the Xeon Platinum 8380.

Feature	EPYC 7543	Xeon Platinum 8380
Cores / Threads	32 / 64	40 / 80+25%
Boost Clock	3.7 GHz+9%	3.4 GHz
Base Clock	2.8 GHz+22%	2.3 GHz
L3 Cache	256 MB (total)+327%	60 MB (total)
L2 Cache	512 kB (per core)	1 MB (per core)+100%
Process	7 nm+-30%	10 nm
Architecture	Milan (2021−2023)	Ice Lake-SP (2021)
PassMark	62,952+1%	62,318
Geekbench 6 Single	—	1,300
Geekbench 6 Multi	—	40,000

🧠

Memory & Platform

The EPYC 7543 uses the SP3 socket (PCIe 4.0), while the Xeon Platinum 8380 uses LGA4189 (PCIe 4.0) — making them incompatible on the same motherboard. Both support up to 3200 memory speed. The Xeon Platinum 8380 supports up to 6144 GB of RAM compared to 4096 GB — 50% more capacity for professional workloads. Both feature 8-channel memory with ECC support. PCIe lanes: 128 (EPYC 7543) vs 64 (Xeon Platinum 8380) — the EPYC 7543 offers 64 more lanes for additional GPUs or NVMe drives. Chipset compatibility: SP3 (EPYC 7543) and C621A (Xeon Platinum 8380).

Feature	EPYC 7543	Xeon Platinum 8380
Socket	SP3	LGA4189
PCIe Generation	PCIe 4.0	PCIe 4.0
Max RAM Speed	3200	DDR4-3200
Max RAM Capacity	4096 GB	6144 GB+50%
RAM Channels	8	8
ECC Support	Yes	Yes
PCIe Lanes	128+100%	64

🔧

Advanced Features

Neither processor supports overclocking. Only the Xeon Platinum 8380 supports AVX-512 instructions — important for machine learning and scientific applications. Both support VT-x, VT-d virtualization. Primary use case: Xeon Platinum 8380 targets Datacenter. Direct competitor: EPYC 7543 rivals Xeon Platinum 8380; Xeon Platinum 8380 rivals EPYC 7543.

Feature	EPYC 7543	Xeon Platinum 8380
Integrated GPU	No	No
IGPU Model	None	None
Unlocked	No	No
AVX-512	No	Yes
Virtualization	VT-x, VT-d	VT-x, VT-d
Target Use	—	Datacenter

💰

Value Analysis

At launch, the EPYC 7543 was priced at $10257, while the Xeon Platinum 8380 came in at $2010. On launch pricing ($10257 vs $2010), Xeon Platinum 8380 was $8247 cheaper. In terms of value on MSRP (PassMark points per dollar), the EPYC 7543 delivers 6.1 pts/$ vs 31.0 pts/$ for the Xeon Platinum 8380 — making the Xeon Platinum 8380 the 133.9% better value option.

Feature	EPYC 7543	Xeon Platinum 8380
MSRP	$10257	$2010-80%
Performance per Dollar	6.1	31.0+408%
Release Date	2021	2021

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