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EPYC 4565P vs EPYC 7543

CPUCPUGPUGPU
AMD

EPYC 4565P

16 Cores32 Thrd170 WWMax: 5.7 GHz2025
EPYC family
·······
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VS
AMD

EPYC 7543

32 Cores64 Thrd225 WWMax: 3.7 GHz2021
EPYC family
·······
Buy on Amazon

EPYC 4565P vs EPYC 7543 Performance Spectrum

EPYC 4565P
16 / 32
64,068
+1.8%
brand logoRyzen 7 7700X
brand logoRyzen 7 8840HX
brand logoRyzen Threadripper PRO 7945WX
brand logoRyzen Threadripper PRO 9945WX
brand logoRyzen Threadripper 3990X
brand logoRyzen Threadripper 9960X
brand logoRyzen Threadripper PRO 9975WX
brand logoRyzen Threadripper PRO 7985WX
EPYC 7543
32 / 64
62,952
0.0%
brand logoRyzen AI 9 HX 370
brand logoRyzen AI Max 390
brand logoRyzen Threadripper PRO 5955WX
brand logoRyzen 9 9955HX
brand logoRyzen Threadripper 3990X
brand logoRyzen Threadripper 9960X
brand logoRyzen Threadripper PRO 9975WX
brand logoRyzen Threadripper PRO 7985WX

About PassMark

PassMark CPU Mark evaluates processor speed through complex mathematical computations. It provides a reliable metric to compare multi-core performance, where higher scores indicate faster processing for multitasking, gaming, and heavy workloads.

EPYC 4565P vs EPYC 7543 FPS Benchmarks

Predicted gaming performance across popular games. Tested paired with GeForce RTX 5090 to isolate CPU performance.

Search any supported game below to compare 1080p FPS for both components.

Path of Exile 2

Path of Exile 2

1080P
EPYC 4565P
low298 FPS
medium271 FPS
high224 FPS
ultra188 FPS
1080P
EPYC 7543
low198 FPS
medium161 FPS
high129 FPS
ultra100 FPS
Counter-Strike 2

Counter-Strike 2

1080P
EPYC 4565P
low687 FPS
medium589 FPS
high440 FPS
ultra378 FPS
1080P
EPYC 7543
low507 FPS
medium443 FPS
high354 FPS
ultra288 FPS
League of Legends

League of Legends

1080P
EPYC 4565P
low891 FPS
medium707 FPS
high624 FPS
ultra535 FPS
1080P
EPYC 7543
low850 FPS
medium705 FPS
high657 FPS
ultra580 FPS
Valorant

Valorant

1080P
EPYC 4565P
low1106 FPS
medium991 FPS
high867 FPS
ultra781 FPS
1080P
EPYC 7543
low992 FPS
medium900 FPS
high775 FPS
ultra671 FPS
Among Us

Among Us

1080P
EPYC 4565P
low60 FPS
medium60 FPS
high60 FPS
ultra60 FPS
1080P
EPYC 7543
low60 FPS
medium60 FPS
high60 FPS
ultra60 FPS
Apex Legends

Apex Legends

1080P
EPYC 4565P
low300 FPS
medium300 FPS
high300 FPS
ultra300 FPS
1080P
EPYC 7543
low300 FPS
medium300 FPS
high300 FPS
ultra300 FPS
ARC Raiders

ARC Raiders

1080P
EPYC 4565P
low346 FPS
medium267 FPS
high242 FPS
ultra209 FPS
1080P
EPYC 7543
low300 FPS
medium229 FPS
high207 FPS
ultra186 FPS
Baldur's Gate 3

Baldur's Gate 3

1080P
EPYC 4565P
low283 FPS
medium253 FPS
high195 FPS
ultra159 FPS
1080P
EPYC 7543
low250 FPS
medium222 FPS
high175 FPS
ultra141 FPS
Call of Duty: Black Ops 6

Call of Duty: Black Ops 6

1080P
EPYC 4565P
low383 FPS
medium341 FPS
high295 FPS
ultra253 FPS
1080P
EPYC 7543
low317 FPS
medium284 FPS
high263 FPS
ultra221 FPS
Call of Duty: Warzone

Call of Duty: Warzone

1080P
EPYC 4565P
low302 FPS
medium288 FPS
high243 FPS
ultra228 FPS
1080P
EPYC 7543
low234 FPS
medium206 FPS
high173 FPS
ultra161 FPS
Check FPS with Custom Builds

EPYC 4565P vs EPYC 7543: Pros, Cons & Final Verdict

See where each CPU makes more sense in practice: gaming, heavier work, platform cost, power draw, and upgrade path.

EPYC 4565P

2025

Why buy it

  • ✅Better for gaming: +28.3% higher average FPS across 50 shared CPU benchmark tests.
  • ✅Costs $7,527 less on MSRP ($2,730 MSRP vs $10,257 MSRP).
  • ✅Delivers 282.4% more PassMark for each dollar spent, at 23.5 vs 6.1 PassMark/$ ($2,730 MSRP vs $10,257 MSRP).
  • ✅Draws 170W instead of 225W, a 55W reduction.
  • ✅Newer platform on AM5 with DDR5 support instead of SP3 and DDR4.

Trade-offs

  • ❌Smaller total L3 cache (64 MB vs 256 MB).

EPYC 7543

2021

Why buy it

  • ✅+300% larger total L3 cache (256 MB vs 64 MB).
  • ✅357.1% more PCIe lanes (128 vs 28) for storage and expansion-heavy builds.

Trade-offs

  • ❌Worse for gaming: lower average FPS than EPYC 4565P across 50 shared CPU benchmark tests.
  • ❌Lower PassMark (62,952 vs 64,068).
  • ❌Lower PassMark per dollar, at 6.1 vs 23.5 PassMark/$ ($10,257 MSRP vs $2,730 MSRP).
  • ❌32.4% higher power demand at 225W vs 170W.
  • ❌Older platform position on SP3 with DDR4, while EPYC 4565P moves to AM5 and DDR5.

Quick Answers

So, is EPYC 4565P better than EPYC 7543?
Yes. EPYC 4565P is the better all-around CPU here. It gives you a 28.3% average FPS lead across 50 shared CPU game tests in our data, 1.8% better PassMark, and the stronger long-term platform, which is enough to make it the stronger overall pick.
Which one is better for gaming?
If gaming is the priority, EPYC 4565P is the better pick. According to our tests, it delivers 28.3% more average FPS across 50 shared CPU game tests.
Which one is better for streaming, content creation, and heavy multitasking?
For streaming, content creation, and heavier multitasking, EPYC 4565P is the stronger fit. You are getting 1.8% better PassMark, backed by 16 cores and 32 threads.
Which one is the smarter buy today, not just the cheaper CPU?
EPYC 4565P is the better buy right now. EPYC 4565P comes in $7,527 cheaper on MSRP at $2,730 MSRP versus $10,257 MSRP, and it still gives you a 28.3% average FPS lead across 50 shared CPU game tests in our data. It is also 282.4% better value on MSRP (23.5 vs 6.1 PassMark/$), so you are getting the faster CPU without taking a value hit on paper.
Which one is more future-proof for 2026 and beyond?
EPYC 4565P makes more sense long term for 2026 and beyond. You are getting a newer CPU generation (2025 vs 2021), a healthier platform with AM5 and DDR5 instead of SP3, more multi-core headroom with 16 cores / 32 threads instead of 32/64, and AVX-512 support for heavier modern compute workloads. That gives you a healthier platform runway for motherboard, RAM, and later CPU upgrades.

EPYC 4565P vs EPYC 7543 Technical Specifications

Side-by-side specs, architecture details, clocks, memory, power, and platform differences.

AMD

EPYC 4565P

The EPYC 4565P is manufactured by AMD. It was released in 13 May 2025 (less than a year ago). It is based on the Grado (2025) architecture. It features 16 cores and 32 threads. Base frequency is 4.3 GHz, with boost up to 5.7 GHz. L3 cache: 64 MB (total). L2 cache: 1 MB (per core). Built on 4 nm process technology. Socket: AM5. Thermal design power (TDP): 170 Watt. Memory support: DDR5. Passmark benchmark score: 64,068 points. Launch price was $589.

AMD

EPYC 7543

The EPYC 7543 is manufactured by AMD. It was released in 15 March 2021 (4 years ago). It is based on the Milan (2021−2023) architecture. It features 32 cores and 64 threads. Base frequency is 2.8 GHz, with boost up to 3.7 GHz. L3 cache: 256 MB (total). L2 cache: 512 kB (per core). Built on 7 nm+ process technology. Socket: SP3. Thermal design power (TDP): 225 Watt. Memory support: DDR4-3200. Passmark benchmark score: 62,952 points. Launch price was $3,761.

⚡

Processing Power

The EPYC 4565P packs 16 cores / 32 threads, while the EPYC 7543 offers 32 cores / 64 threads — the EPYC 7543 has 16 more cores. Boost clocks reach 5.7 GHz on the EPYC 4565P versus 3.7 GHz on the EPYC 7543 — a 42.6% clock advantage for the EPYC 4565P (base: 4.3 GHz vs 2.8 GHz). The EPYC 4565P uses the Grado (2025) architecture (4 nm), while the EPYC 7543 uses Milan (2021−2023) (7 nm+). In PassMark, the EPYC 4565P scores 64,068 against the EPYC 7543's 62,952 — a 1.8% lead for the EPYC 4565P. L3 cache: 64 MB (total) on the EPYC 4565P vs 256 MB (total) on the EPYC 7543.

FeatureEPYC 4565PEPYC 7543
Cores / Threads
16 / 32
32 / 64+100%
Boost Clock
5.7 GHz+54%
3.7 GHz
Base Clock
4.3 GHz+54%
2.8 GHz
L3 Cache
64 MB (total)
256 MB (total)+300%
L2 Cache
1 MB (per core)+100%
512 kB (per core)
Process
4 nm-43%
7 nm+
Architecture
Grado (2025)
Milan (2021−2023)
PassMark
64,068+2%
62,952
🧠

Memory & Platform

The EPYC 4565P uses the AM5 socket (PCIe 4.0), while the EPYC 7543 uses SP3 (PCIe 4.0) — making them incompatible on the same motherboard. Maximum memory speed reaches 5600 on the EPYC 4565P versus 3200 on the EPYC 7543 — the EPYC 4565P supports 75% faster memory, which can translate to measurable gains in memory-sensitive workloads. The EPYC 7543 supports up to 4096 of RAM compared to 192 — 2033.3% more capacity for professional workloads. Memory channels: 2 (EPYC 4565P) vs 8 (EPYC 7543). PCIe lanes: 28 (EPYC 4565P) vs 128 (EPYC 7543) — the EPYC 7543 offers 100 more lanes for additional GPUs or NVMe drives. Chipset compatibility: AM5 (EPYC 4565P) and SP3 (EPYC 7543).

FeatureEPYC 4565PEPYC 7543
Socket
AM5
SP3
PCIe Generation
PCIe 4.0
PCIe 4.0
Max RAM Speed
5600+75%
3200
Max RAM Capacity
192
4096+2033%
RAM Channels
2
8+300%
ECC Support
Yes
Yes
PCIe Lanes
28
128+357%
🔧

Advanced Features

Only the EPYC 4565P has an unlocked multiplier for overclocking — a significant advantage for enthusiasts seeking extra performance. Only the EPYC 4565P supports AVX-512 instructions — important for machine learning and scientific applications. Virtualization support: VT-x, VT-d, AMD-V (EPYC 4565P) vs VT-x, VT-d (EPYC 7543). The EPYC 4565P includes integrated graphics (AMD Radeon Graphics), while the EPYC 7543 requires a dedicated GPU. Direct competitor: EPYC 4565P rivals Core Ultra 9 285K; EPYC 7543 rivals Xeon Platinum 8380.

FeatureEPYC 4565PEPYC 7543
Integrated GPU
Yes
No
IGPU Model
AMD Radeon Graphics
None
Unlocked
Yes
No
AVX-512
Yes
No
Virtualization
VT-x, VT-d, AMD-V
VT-x, VT-d
💰

Value Analysis

At launch, the EPYC 4565P was priced at $2730, while the EPYC 7543 came in at $10257. On launch pricing ($2730 vs $10257), EPYC 4565P was $7527 cheaper. In terms of value on MSRP (PassMark points per dollar), the EPYC 4565P delivers 23.5 pts/$ vs 6.1 pts/$ for the EPYC 7543 — making the EPYC 4565P the 117.1% better value option.

FeatureEPYC 4565PEPYC 7543
MSRP
$2730-73%
$10257
Performance per Dollar
23.5+285%
6.1
Release Date
2025
2021
Search EPYC 4565P on AmazonSearch EPYC 7543 on Amazon

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